The M2B initiative takes advantage of the DOE investment in High Performance Computing through the National Energy Research Scientific Computing Center (NERSC). NERSC is the primary scientific computing facility for DOE’s Office of Science and a world leader in accelerating scientific discovery through computation and data analysis. More than 5,000 scientists use NERSC to perform basic research across a wide range of disciplines, including climate modeling, high energy physics, new materials, simulations of the early universe and a host of other scientific endeavors. Within M2B, HPC activities include complex biogeochemical model simulations and analysis of multi-dimensional and complex biological systems data from ‘omics and imaging workflows.